When the spleen gets larger, it can press on the stomach, which makes people feel full when they eat even a small amount.Ĭirculation system symptoms: In hyperviscosity syndrome, the thickened blood causes poor brain circulation, leading to problems like headache, confusion, and dizziness. In the upper part of the abdomen, the liver is on the right and the spleen on the left. Swollen abdomen (belly): WM can sometimes make the spleen or liver bigger, making the belly look swollen. They are seen less often in WM than in most other lymphomas. Enlarged lymph nodes are usually about 1 or 2 inches (2.5-5 cm) across. Less common signs and symptoms of WMĮnlarged lymph nodes: These usually appear as lumps under the skin around the neck, in the groin, or in the armpits. This can lead to numbness or a painful “pins and needles” sensation in the feet and legs, which is called neuropathy. Neuropathy: In some people with WM, the abnormal antibody can attack and damage nerves outside the brain. Loss of appetite: Some people with WM lose their appetite.įever, sweats, weight loss: WM, like other lymphomas, can cause fevers (without an infection), drenching night sweats, and weight loss (without trying). Some people also feel weak when the blood thickens from the buildup of the abnormal protein. It can be caused by anemia (too few red blood cells), which can happen when the WM cells crowd out normal cells in the bone marrow. Weakness: This is one of the most common symptoms of WM. Not all people with WM develop hyperviscosity, cryoglobulins, or amyloidosis. This buildup can lead to heart and kidney problems. A condition called amyloidosis can occur when a part of the IgM antibody (called the light chain) builds up in organs like the heart and kidneys.Cryoglobulins can cause pain or other problems in these areas if a person is exposed to cooler temperatures. If the M protein only thickens the blood in cooler parts of the body (like in the tip of the nose, ears, fingers, and toes), it is called a cryoglobulin.This can cause problems such as poor circulation to the brain, which can lead to symptoms like those from a stroke. In hyperviscosity syndrome, too much of the M protein in the blood can cause it to become too “thick.” (This is not the kind of thickness that can be treated with drugs known as blood thinners.) When the blood gets too thick, it has trouble moving through blood vessels.Other WM symptoms are caused by the large amounts of abnormal IgM antibody (M protein) made by the cancer cells: For example, weight loss, fever, night sweats, and swollen lymph nodes can be seen in many types of NHL. When WM does cause symptoms, some of them can be like those seen with other types of non-Hodgkin lymphoma (NHL). WM found this way is sometimes called asymptomatic or smoldering WM. Instead, it’s found when the person has blood tests done for some other reason. Sometimes, Waldenstrom macroglobulinemia (WM) isn’t causing any symptoms when it’s first found.
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